首页 > Tocris > Tocris/PF 04217903 mesylate/4239/10/10 mg

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Tocris/PF 04217903 mesylate/4239/10/10 mg

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4239/10

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Tocris

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Description: Highly selective MET inhibitor Chemical Name: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators Datasheets References Biological Activity Highly selective, high affinity MET inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases. Licensing Information Sold for research purposes under agreement from Pfizer Inc. Technical Data M. Wt 468.49 Formula C19H16N8O.CH3SO3H Storage Store at +4°C Purity ≥98% (HPLC) CAS Number 956906-93-7 PubChem ID 24852079 InChI Key HBEMHKVWZJTVOC-UHFFFAOYSA-N Smiles OCCN1N=CC(C2=CN=C3C(N(CC4=CC=C(N=CC=C5)C5=C4)N=N3)=N2)=C1.CS(=O)(O)=O The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only. Solubility Data Solvent Max Conc. mg/mL Max Conc. mM Solubility DMSO 46.85 100 Preparing Stock Solutions The following data is based on the product molecular weight 468.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg 1 mM 2.13 mL 10.67 mL 21.35 mL 5 mM 0.43 mL 2.13 mL 4.27 mL 10 mM 0.21 mL 1.07 mL 2.13 mL 50 mM 0.04 mL 0.21 mL 0.43 mL Molarity Calculator Molarity Calculator Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator Reconstitution Calculator Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Product Datasheets Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS References References are publications that support the products' biological activity. Eder et al (2009) Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin.Cancer Res. 15 2207 PMID: 19318488 Timofeevski et al (2009) Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry 48 5339 PMID: 19459657 Underiner et al (2010) Discovery of small molecule c-Met inhibitors: evolution and profiles of clinical candidates. Anticancer Agents Med.Chem. 10 7 PMID: 20015007 Cui et al (2012) Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6- J.Med.Chem. 55 8091 PMID: 22924734 Keywords: PF 04217903 mesylate, supplier, pfizer, PF04217903, c-met, met, mesenchymal, epithelial, transition, factor, hgfr, receptors, tyrosine, kinase, rtk, inhibitors, inhibits, anticancer, selective, MET, Receptors, MET, Receptors, Tocris Bioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins