Description:Potent,selectivedopamineuptakeinhibitorChemicalName:1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazinedihydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityAverypotentandselectiveinhibitorofdopamineuptake(IC50forinhibitionof[3H]-dopamineuptakeinratstriatalsynaptosomesis1.8nM).TechnicalDataM.Wt485.5FormulaC28H32N2O.2HClStorageDesiccateat-20°CPurity≥99%(HPLC)CASNumber67469-75-4PubChemID24744862InChIKeyHJDXBLLTRMCYNC-JFXLULTRSA-NSmilesCl[H].Cl[H].C(CN1CCN(CC=CC2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO24.2750mMwithgentlewarmingethanol2.435mMwithgentlewarmingwater4.8610mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight485.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.06mL10.3mL20.6mL5mM0.41mL2.06mL4.12mL10mM0.21mL1.03mL2.06mL50mM0.04mL0.21mL0.41mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.BonnetandConstentin(1986)GBR12783,apotentandselectiveinhibitorofdopamineuptake:biochemicalstudiesinvivoandexvivo.Eur.J.Pharmacol.121199PMID:3754516Do-Regoetal(1999)Evidenceforthesequentialformationoftwocomplexesbetweenanuptakeinhibitor,GBR12783[1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine],andtheneuronaltransporterofdopamine.J.NeuRochem.72396PMID:9886093Girosetal(1992)Cloning,pharmacologicalcharacterizationandchromosomeassignmentofthehumandopaminetransporter.Mol.Pharmacol.42383PMID:1406597Vaugeoisetal(1992)Invivolabellingoftheneuronaldopamineuptakecomplexinthemousestriatumby[3H]GBR12783.Eur.J.Pharmacol.21077PMID:1350989Keywords:GBR12783dihydrochloride,supplier,Potent,selective,dopamine,reuptake,inhibitors,inhibits,DAT,Dopamine,Transporters,Monoamine,Neurotransmitter,GBR12783,dihydrochloride,Dopamine,Transporters,Dopamine,Transporters,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌,其产品也广为各大药厂、大学、研究机构,超过五万名科学研究者所采用。 目前,產品內容已超過一千六百種以上,並每年持續不斷的增加新的產品。目前,产品内容已超过一千六百种以上,并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔(Bristol)的高品质试剂提供商,共有2000多种产品,主要集中在神经科学和信号传导领域,产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等,主要产品包括GPCR ligands,神经传递素,离子通道调控剂,信号通路抑制剂等,这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者,其生产的影响神经系统的化学物质被多次引用,这些物质很多都来自Jeff Watkins(Tocris 的创立人)在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括:
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分:
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System