Description:SelectiveBaxactivator;inducesBax-mediatedapoptosisChemicalName:3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione4-[2-(2-Ethoxyphenyl)hydrazone]Purity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityBaxactivator(EC50=3.3μM);bindsattheBH3-bindingsite.SelectiveforBaxoverotherantiapoptoticandproapoptoticproteins.TriggersBaxoligomerizationinvitro;inducesBax-mediatedapoptosisinmouseembryonicfibroblasts.TechnicalDataM.Wt405.47FormulaC21H19N5O2SStorageStoreat+4°CPurity≥99%(HPLC)CASNumber331244-89-4PubChemID5754137InChIKeyKOCVKGYKBLJEPK-LYBHJNIJSA-NSmilesCC(/C1=NNC2=C(OCC)C=CC=C2)=NN(C3=NC(C4=CC=CC=C4)=CS3)C1=OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO4.0510PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight405.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.47mL12.33mL24.66mL5mM0.49mL2.47mL4.93mL10mM0.25mL1.23mL2.47mL50mM0.05mL0.25mL0.49mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Gavathiotisetal(2012)Directandselectivesmall-moleculeactivationofproapoptoticBAX.Nat.Chem.Biol.8639PMID:22634637Keywords:BAM7,supplier,BAM7,bax,proapoptotic,apoptosis,activators,BH3,binding,site,inducers,oligomerization,selective,Bcl-2,Family,Apoptosis,Inducers,Bcl-2,Family,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
