Description:InhibitorofNF-κBactivation;anti-inflammatoryChemicalName:(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-onePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityChaloneanalogthatdisplayanti-inflammatoryactivity.InhibitsNOandPGE2productionfromLPS-andIFN-γ-inducedRAWcellsandinhibitsTXB2productionviatheCOX-1andCOX-2pathways.InhibitsNF-κBactivationviainhibitionofIκBαdegradationandphosphorylation,IκBkinaseactivationandNF-κBnucleartranslocation.TechnicalDataM.Wt270.28FormulaC16H14O4StorageStoreat+4°CPurity≥98%(HPLC)CASNumber19309-14-9PubChemID641785InChIKeyNYSZJNUIVUBQMM-BQYQJAHWSA-NSmilesOC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO27.03100ethanol5.4120PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight270.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.7mL18.5mL37mL5mM0.74mL3.7mL7.4mL10mM0.37mL1.85mL3.7mL50mM0.07mL0.37mL0.74mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Leeetal(2006)Blockadeofnuclearfactor-κBsignalingpathwayandanti-inflammatoryactivityofCardamomin,achalconeanalogfromAlpinaconchigera.J.Pharmacol.Exp.Ther.316271PMID:16183703Ahmadetal(2006)Cardamonin,inhibitspro-inflammatorymediatorsinactivatedRAW264.7cellsandwholeblood.Eur.J.Pharmacol.538188PMID:16650843Israfetal(2007)CardamonininhibitsCOXandiNOSexpressionviainhibitionofp65NF-κBnucleartranslocationandIκ-BphosphorylationinRAW264.7macrophagecells.Mol.Immunol.44673PMID:16777230Keywords:Cardamonin,supplier,Nf-kappaB,NF-kB,NF-κB,inhibitors,activation,inhibits,anti-inflammatory,transcription,factors,nuclear,factor,kappa,B,signaling,signalling,NF-kB/IkB,NF-kB/IkB,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
