Description: PI 3-kinase inhibitor
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.
Technical Data
M. Wt
254.25
Formula
C12H10N6O
Storage
Desiccate at RT
Purity
≥98% (HPLC)
CAS Number
925705-73-3
PubChem ID
17751063
InChI Key
UOORQSPLBHUQDQ-UHFFFAOYSA-N
Smiles
NC1=NC(N)=C2C(N=CC(C3=CC=CC(O)=C3)=N2)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
2.54
10
Preparing Stock Solutions
The following data is based on the product molecular weight 254.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.93 mL
19.67 mL
39.33 mL
5 mM
0.79 mL
3.93 mL
7.87 mL
10 mM
0.39 mL
1.97 mL
3.93 mL
50 mM
0.08 mL
0.39 mL
0.79 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Doukas
et al (2006) Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc.Natl.Acad.Sci.USA 103 19866 PMID: 17172449
Palanki
et al (2007) Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J.Med.Chem. 50 4279 PMID: 17685602
Keywords: TG 100713, supplier, TG100713, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, ip3kβ, inhibitors, inhibits, PI, 3-Kinase, PI, 3-Kinase, Tocris Bioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
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