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Tocris/SB 3CT/6088/10/10 mg

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6088/10

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Tocris

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Description: Selective high affinity MMP2 inhibitor Chemical Name: 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators Datasheets References Biological Activity Selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable. Technical Data M. Wt 306.4 Formula C15H14O3S2 Storage Store at -20°C Purity ≥98% (HPLC) CAS Number 292605-14-2 PubChem ID 9883002 InChI Key LSONWRHLFZYHIN-UHFFFAOYSA-N Smiles O=S(CC1CS1)(C2=CC=C(C=C2)OC3=CC=CC=C3)=O The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only. Solubility Data Solvent Max Conc. mg/mL Max Conc. mM Solubility DMSO 30.64 100 ethanol 6.13 20 Preparing Stock Solutions The following data is based on the product molecular weight 306.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg 1 mM 3.26 mL 16.32 mL 32.64 mL 5 mM 0.65 mL 3.26 mL 6.53 mL 10 mM 0.33 mL 1.63 mL 3.26 mL 50 mM 0.07 mL 0.33 mL 0.65 mL Molarity Calculator Molarity Calculator Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator Reconstitution Calculator Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Product Datasheets Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS References References are publications that support the products' biological activity. Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401 PMID: 16000631 Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125 PMID: 11278946 Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730 PMID: 23077716 Keywords: SB 3CT, supplier, SB3CT, Selective, high, affinity, MMP2, inhibitors, MMP9, blood-brain, barrier, BBB, permeable, matrix, metalloproteinases, neuroprotective, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience

Tocris Bioscience.png

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins