Description:Potent,selectiveGABABpositiveallostericmodulatorChemicalName:5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranonePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectiveGABABreceptorpositiveallostericmodulatorthatincreasesthepotencyandefficacyofGABA(>15-foldand>149%respectively).Exhibitsanxiolyticactivityinvivoandisorallyactive.CompoundLibrariesracBHFFisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt330.34FormulaC17H21F3O3StorageStoreat+4°CPurity≥98%(HPLC)CASNumber123557-91-5PubChemID4332683InChIKeyRVNOANDLZIIFHB-UHFFFAOYSA-NSmilesCC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO33.03100ethanol33.03100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight330.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.03mL15.14mL30.27mL5mM0.61mL3.03mL6.05mL10mM0.3mL1.51mL3.03mL50mM0.06mL0.3mL0.61mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Malherbeetal(2008)Characterizationof(R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-oneasapositiveallostericmodulatorofGABABreceptors.Br.J.Pharmacol.154797PMID:18536733Koeketal(2013)DiscriminativestimuluseffectsoftheGABABreceptor-positivemodulatorrac-BHFF:comparisonwithGABABreceptoragoNISTsanddrugsofabuse.J.Pharmacol.Exp.Ther.344553PMID:23275067Keywords:racBHFF,supplier,Potent,selective,GABAB,positive,allosteric,modulators,Receptors,GABAB,Receptors,GABAB,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
