Description:MitochondrialprotonophoreuncouplerChemicalName:N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxADIazolo[3,4-b]pyrazine-5,6-diaminePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityMitochondrialprotonophoreuncoupler;uncouplesoxidativephosphorylationinL6myoblastmitochondriainvitro(EC50=270nM).Doesnotdepolarizetheplasmamembrane.Protectsmicefromacuterenalischemic-reperfusioninjury.TechnicalDataM.Wt340.29FormulaC16H10F2N6OStorageStoreat-20°CPurity≥98%(HPLC)CASNumber210302-17-3PubChemID565708InChIKeyOEGJBRZAJRPPHL-UHFFFAOYSA-NSmilesFC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)FThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO34.03100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight340.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.94mL14.69mL29.39mL5mM0.59mL2.94mL5.88mL10mM0.29mL1.47mL2.94mL50mM0.06mL0.29mL0.59mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Kenwoodetal(2015)Structure-activityrelationshipsoffurazano[3,4-b]pyrazinesasmitochondrialuncouplers.Bioorg.Med.Chem.Lett.254858PMID:26119501Kenwoodetal(2013)Identificationofanovelmitochondrialuncouplerthatdoesnotdepolarizetheplasmamembrane.Mol.Metab.3114PMID:24634817Keywords:BAM15,supplier,BAM15,mitochondrial,uncouplers,oxidative,phosphorylation,respiration,protonophores,renal,ischemic-reperfusion,injury,Oxidative,Phosphorylation,Oxidative,Phosphorylation,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
