Description: Inhibitor of NF-κB activation; anti-inflammatory
Chemical Name: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.
Technical Data
M. Wt
270.28
Formula
C16H14O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
CAS Number
19309-14-9
PubChem ID
641785
InChI Key
NYSZJNUIVUBQMM-BQYQJAHWSA-N
Smiles
OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
27.03
100
ethanol
5.41
20
Preparing Stock Solutions
The following data is based on the product molecular weight 270.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.7 mL
18.5 mL
37 mL
5 mM
0.74 mL
3.7 mL
7.4 mL
10 mM
0.37 mL
1.85 mL
3.7 mL
50 mM
0.07 mL
0.37 mL
0.74 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Lee
et al (2006) Blockade of nuclear factor-κB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271 PMID: 16183703
Ahmad
et al (2006) Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur.J.Pharmacol. 538 188 PMID: 16650843
Israf
et al (2007) Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells. Mol.Immunol. 44 673 PMID: 16777230
Keywords: Cardamonin, supplier, Nf-kappaB, NF-kB, NF-κB, inhibitors, activation, inhibits, anti-inflammatory, transcription, factors, nuclear, factor, kappa, B, signaling, signalling, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌,其产品也广为各大药厂、大学、研究机构,超过五万名科学研究者所采用。 目前,產品內容已超過一千六百種以上,並每年持續不斷的增加新的產品。目前,产品内容已超过一千六百种以上,并每年持续不断的增加新的产品。
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按照研究领域细分:
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