Description:InhibitorofRNApolymeraseIIChemicalName:cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4→8)-sulfide(R)-S-oxidePurity:≥95%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityInhibitorofRNApolymeraseII.Inhibitstranscriptionineukaryoticcells.BindsandblocksthelargestsubunitsofRNApolymeraseII,preventingnewribonucleotidesfromincorporatingintothenascentRNAchain.Potentamatoxin.TechnicalDataM.Wt918.97FormulaC39H54N10O14SStorageStoreat-20°CPurity≥95%(HPLC)CASNumber23109-05-9PubChemID441541InChIKeyCIORWBWIBBPXCG-JAXJKTSHSA-NSmilesO=[C@@](N[C@@](C(N[C@@H](CC2=C(S4=O)NC3=C2C=CC(O)=C3)C(NCC(N[C@]([H])5[C@@H](C)CC)=O)=O)=O)([H])[C@@H](C)[C@@H](O)CO)[C@@H]1C[C@@H](O)CN1C([C@H](CC(N)=O)NC([C@H](C4)NC(CNC5=O)=O)=O)=OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityethanol4.595water4.595PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight918.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.09mL5.44mL10.88mL5mM0.22mL1.09mL2.18mL10mM0.11mL0.54mL1.09mL50mM0.02mL0.11mL0.22mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Casseetal(1999)Thetranscriptionalinhibitors,actinomycinDandα-amanitin,activatetheHIV-1promoterandfavorphosphorylationoftheRNApolymeraseIIC-terminaldomain.J.Biol.Chem.27416097PMID:10347161Rahaetal(2010)CloseassociationofRNApolymeraseIIandmanytranscriptionfactorswithPolIIIgenes.Proc.Natl.Acad.Sci.1073639PMID:Keywords:alpha-Amanitin,supplier,alpha-Amanitin,a-Amanitin,α-Amanitin,RNA,polymerases,II,inhibitors,inhibits,RNA/DNA,Polymerase,DNA,,RNA,and,Protein,Synthesis,RNA,Polymerase,RNA/DNA,Polymerase,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
