产品说明
Description:PotentandselectiveATP-competitiveinhibitorofChk1andChk2ChemicalName:3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamidehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectiveATP-competitiveinhibitorofChk1andChk2(IC50valesare5nMforbothkinases);displaysatleast>10foldselectivityoverapanelof164kinases.PotentiatescytotoxicityofDNA-damagingagents.Activeinvivo.LicensingInformationSoldforresearchpurposesunderagreementfromAstraZenecaCompoundLibrariesAZD7762hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt398.88FormulaC17H19FN4O2S.HClStorageStoreat-20°CPurity≥98%(HPLC)CASNumber1246094-78-9PubChemID56972142InChIKeyWFZBLOIXZRZEDG-YDALLXLXSA-NSmilesFC1=CC=CC(C2=CC(NC(N)=O)=C(C(N[C@@H]3CNCCC3)=O)S2)=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO39.89100water39.89100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight398.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.51mL12.54mL25.07mL5mM0.5mL2.51mL5.01mL10mM0.25mL1.25mL2.51mL50mM0.05mL0.25mL0.5mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Zabludoffetal(2008)AZD7762,anovelcheckpointkinaseinhibitor,drivescheckpointabrogationandpotentiatesDNA-targetedtherapies.Mol.CancerTher.72955PMID:18790776Morganetal(2010)MechanismofrADIosensitizationbytheChk1/2inhibitorAZD7762involvesabrogationoftheG2checkpointandinhibitionofhomologousrecombinationalDNArepair.CancerRes.704972PMID:20501833Keywords:AZD7762hydrochloride,supplier,AZD7762,hydrochloride,Potent,selective,ATP,competitive,inhibitors,inhibits,Chk1,Chk2,checkpoint,kinases,Checkpoint,Kinases,Checkpoint,Control,Kinases,Checkpoint,Kinases,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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