产品说明
Description:InhibitsviralDNApolymerase;antiherpeticagentAlternativeNames:Aciclovir,AcycloguanosineChemicalName:2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-onePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityAntiviralagent,activeagainstherpessimplexvirusesHSV-1andHSV-2(EC50valuesare0.85and0.86μMrespectively).InterfereswithviralDNApolymerizationthroughcompetitiveinhibitionwithguanosinetriphosphate.InducesapoptosisincellstransfectedwithHSV-TK(suicidalgenetherapy).CompoundLibrariesAcyclovirisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt225.21FormulaC8H11N5O3StorageStoreatRTPurity≥99%(HPLC)CASNumber59277-89-3PubChemID2022InChIKeyMKUXAQIIEYXACX-UHFFFAOYSA-NSmilesNC1=NC(=O)C2=C(N1)N(COCCO)C=N2Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubility1eq.HCl11.2650DMSO4.520PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight225.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM4.44mL22.2mL44.4mL5mM0.89mL4.44mL8.88mL10mM0.44mL2.22mL4.44mL50mM0.09mL0.44mL0.89mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Hayashietal(2006)TheroleofaHSVthymidinekinasestimulatingsubstance,scopadulciol,inimprovingtheefficacyofcancergenetherapy.J.Gene.Med.81056PMID:16779868Suzukietal(2006)SynergisticantiviralactivityofacyclovirandvidarABIneagainstherpessimplexvirustypes1and2andvaricella-zostervirus.AntiviralRes.72157PMID:16797734Elionetal(1977)Selectivityofactionofanantiherpeticagent,9-(2-hydroxyethoxymethyl)guanine.Proc.Natl.Acad.Sci.USA.745716PMID:Keywords:Acyclovir,supplier,Viral,DNA,polymerases,inhibitors,inhibits,antiherpetic,agent,Synthesis,antiviral,Aciclovir,Acycloguanosine,RNA/DNA,Polymerase,DNA,,RNA,and,Protein,Synthesis,Antivirals,RNA/DNA,Polymerase,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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关于 Tocris | Tocris 生物科学,Tocris/SB 265610/2724/1/1 mg
