Description:MCH1antagoNIST;also5-HT2Bantagonistand5-HT1ApartialagonistChemicalName:N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent,selectiveandorallyactivemelanin-concentratinghormonereceptor1(MCH1)antagonist(IC50valuesare13.5and>10000nMforMCH1andMCH2receptorsrespectively).Exhibitsanxiolyticandantidepressantactivityinrodents.Alsodisplaysaffinityfor5-HT2Band5-HT1Areceptors(IC50valuesare9.66and16.9nMrespectively).TechnicalDataM.Wt461.94FormulaC23H25F2N5O.HClStorageStoreat+4°CPurity≥98%(HPLC)CASNumber510733-97-8PubChemID9934032InChIKeyHUUPKFUYSQNNLO-UHFFFAOYSA-NSmilesO=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO4.6210ethanol11.5525PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight461.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.16mL10.82mL21.65mL5mM0.43mL2.16mL4.33mL10mM0.22mL1.08mL2.16mL50mM0.04mL0.22mL0.43mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Chakietal(2005)Anxiolytic-andantidepressant-likeprofileofATC0065andATC0175:nonpeptidicandorallyactivemelanin-concentratinghormonereceptor1antagonists.J.Pharmacol.Exp.Ther.313831PMID:15677346Chakietal(2005)ATC0175:anorallyactivemelanin-concentratinghormonereceptor1antagonistforthepotentialtreatmentofdepressionandanxiety.CNSDrugRev.11341PMID:16614734Keywords:ATC0175hydrochloride,supplier,MCH1,melanin,concentrating,hormone,receptors,5-HT,SEROtonin,antagonists,ATC0175,hydrochloride,5-HT2b,5-HT1a,partial,MCHR1,MCH1R,Melanin-concentrating,Hormone,Receptors,5-HT2B,Receptors,5-HT1A,Receptors,Melanin-concentrating,Hormone,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
