Description:Selectiveα1DantagoNISTChemicalName:8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dionedihydrochlorideBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivity5-HT1Apartialagonistandhighaffinityα1Dadrenoceptorantagonist(Kivaluesare2,800and600nMatclonedratα1D,ratα1Aandhamsterα1Breceptorsrespectively).Alsoavailableaspartoftheα1-AdrenoceptorTocriset™.TechnicalDataM.Wt458.42FormulaC22H31N3O3.2HClStorageStoreatRTCASNumber21102-95-4PubChemID24744861InChIKeyHZRPUQURUAXOHB-UHFFFAOYSA-NSmilesO=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolubilitySolubleto100mMinwaterPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight458.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.18mL10.91mL21.81mL5mM0.44mL2.18mL4.36mL10mM0.22mL1.09mL2.18mL50mM0.04mL0.22mL0.44mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.GruelandGlaser(1992)Theputative5-HT1AreceptorantagonistsNAN-190andBMY7378arepartialagonistsintheratdorsalraphenucleusinvitro.Eur.J.Pharmacol.211211PMID:1535319Piasciketal(1995)Thespecificcontributionofthenovelalpha-1Dadrenoceptortothecontractionofvascularsmoothmuscle.J.Pharmacol.Exp.Ther.2751583PMID:8531132Sharpetal(1990)Furtherinvestigationoftheinvivopharmacologicalpropertiesoftheputative5-HT1Aantagonist,BMY7378.Eur.J.Pharmacol.176331PMID:1970304YangandEndoh(1997)Pharmacologicalevidenceforβ1D-adrenoceptorsintherabbitventricularmyocardium:analysiswithBMY7378.Br.J.Pharmacol1221541PMID:9422797Keywords:BMY7378dihydrochloride,supplier,Selective,α1D-adrenoceptor,alpha1D-adrenoceptor,a1d-adrenoceptor,α1d-adrenergic,alpha1d-adrenergic,a1d-adrenergic,antagonist,5-HT1A,partial,agonists,Receptors,SEROtonin,BMY7378,dihydrochloride,Adrenergic,Alpha-1,Receptors,5-HT1A,Receptors,Adrenergic,Alpha-1,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
