Description:Selective5-HT1AagoNIST.Enantiomerof8-Hydroxy-DPAThydrobromide(Cat.No.0529)ChemicalName:(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralinhydrobromidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityFull5-HT1ASEROtoninreceptoragonist;moreactiveenantiomer.Reduceshippocampal5-HTlevelsfollowingsystemicadministrationinratsinvivo.Moreactiveenantiomerof8-Hydroxy-DPAThydrobromide(Cat.No.0529).7-Hydroxy-DPAThydrobromide(Cat.No.0706)alsoavailable.TechnicalDataM.Wt328.29FormulaC16H25NO.HBrStorageDesiccateat+4°CPurity≥99%(HPLC)CASNumber78095-19-9PubChemID11957570InChIKeyBATPBOZTBNNDLN-PFEQFJNWSA-NSmilesBr.CCCN(CCC)[C@@H]1CCC2=CC=CC(O)=C2C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO24.6275water24.6275PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight328.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.05mL15.23mL30.46mL5mM0.61mL3.05mL6.09mL10mM0.3mL1.52mL3.05mL50mM0.06mL0.3mL0.61mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Bjorketal(1989)ResolvedN,N-dialkylated2-amino-8-hydroxytetralins:stereoselectiveinteractionswith5-HT1Areceptorsinthebrain.J.Med.Chem.32779PMID:2522991Corrfieldetal(1991)Intrinsicactivityofenantiomersof8-hydroxy-2-(di-n-propylamino)tetralinanditsanaloguesat5-hydroxytryptamine1Areceptorsthatarenegativelycoupledtoadenylatecyclase.Mol.Pharmacol.39780PMID:1828859YoshitakeandKehr(2004)Differentialeffectsof(R)-,(R,S)-and(S)-8-hydroxy-2-(di-n-propylamino)tetralinonhippocampalserotoninreleaseandinductionofhypothermiainawakerats.LifeSci.742865PMID:15050424Keywords:(R)-(+)-8-Hydroxy-DPAThydrobromide,supplier,Selective,5-HT1A,agonists,active,enantiomer,Serotonin,Receptors,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
