首页 > Tocris > Tocris/8-Hydroxy-DPAT hydrobromide/0529/50/50 mg

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Tocris/8-Hydroxy-DPAT hydrobromide/0529/50/50 mg

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0529/50

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Description:Selective5-HT1AagoNIST;alsohasmoderateaffinityfor5-HT7AlternativeNames:8-OH-DPAThydrobromideChemicalName:(±)-8-Hydroxy-2-dipropylaminotetralinhydrobromidePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityThestandardselective5-HT1Aagonist.Alsohasmoderateaffinityfor5-HT7receptors(pKiis6.6atthehuman5-HT7receptorexpressedinHEK293cells).Reduceshippocampal5-HTlevelsfollowingsystemicadministrationinratsinvivo.(R)-(+)-8-Hydroxy-DPAThydrobromide(Cat.No.1080)and7-Hydroxy-DPAThydrobromide(Cat.No.0706)alsoavailable.TechnicalDataM.Wt328.29FormulaC16H25NO.HBrStorageDesiccateat+4°CPurity≥98%(HPLC)CASNumber76135-31-4PubChemID6917794InChIKeyBATPBOZTBNNDLN-UHFFFAOYSA-NSmilesBr.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityethanol1.645water6.5720mMwithgentlewarmingphosphatebufferedsaline4.9215mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight328.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.05mL15.23mL30.46mL5mM0.61mL3.05mL6.09mL10mM0.3mL1.52mL3.05mL50mM0.06mL0.3mL0.61mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.HeltonandColbert(1994)Alterationofin-vitro5-HTreceptorpharmacologyasafunctionofmultipletreatmentwith5-hydroxytryptamineof8-hydroxy-2-(di-N-propylamino)tetralininratisolatedaorta,uterusandfundus,andguineapigisolatedtrachea.J.Pharm.Pharmacol.46902PMID:7897596Middlemissetal(1983)8-OH-DPATdiscriminatesbetweensubtypesofthe5HT1recognitionsite.Eur.J.Pharmacol.90151PMID:6223827Woodetal(2000)Antagonistactivityofmeta-chlorophenylpiperazineandpartialagonistactivityof8-OH-DPATatthe5-HT7receptor.Eur.J.Pharmacol.3961PMID:10822046YoshitakeandKehr(2004)Differentialeffectsof(R)-,(R,S)-and(S)-8-hydroxy-2-(di-n-propylamino)tetralinonhippocampalSEROtoninreleaseandinductionofhypothermiainawakerats.LifeSci.742865PMID:15050424Keywords:8-Hydroxy-DPAThydrobromide,supplier,moderate,affinity,5-HT7,5-HT1A,agonists,Selective,Serotonin,Receptors,5-Hydroxytryptamine,5-HT1,8-OH-DPAT,hydrobromide,5-HT7,Receptors,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins