Description:Selective5-HT1AagoNISTAlternativeNames:TVXQ7821ChemicalName:2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivitySelective5-HT1Areceptoragonist(Ki=10nM).Anxiolyticinvivo.TechnicalDataM.Wt401.48FormulaC19H23N5O3SStorageStoreatRTPurity≥99%(HPLC)CASNumber95847-70-4PubChemID56971InChIKeyTZJUVVIWVWFLCD-UHFFFAOYSA-NSmilesO=C1N(CCCCN2CCN(CC2)C2=NC=CC=N2)S(=O)(=O)C2=CC=CC=C12Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO4.0110PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight401.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.49mL12.45mL24.91mL5mM0.5mL2.49mL4.98mL10mM0.25mL1.25mL2.49mL50mM0.05mL0.25mL0.5mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Majetal(1987)Centralactionofipsapirone,anewanxiolyticdrug,onSEROtoninergic,noradrenergicanddopaminergicfunctions.J.Neural.Transm.701PMID:2889795GlaserandTraber(1985)BindingoftheputativeanxiolyticTVXQ7821tohippocampal5-hydroxytryptamine(5-HT)recognitionsites.Naunyn-Schmied.Arch.Pharmacol.329211PMID:Traberetal(1984)BrainserotoninreceptorsasatargetfortheputativeanxiolyticTVXQ7821.BrainRes.Bull.12741PMID:6541079Keywords:Ipsapirone,supplier,Selective,5-HT1A,agonists,Serotonin,Receptors,TVXQ7821,TVX,Q,7821,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
