产品说明
Description:HighlypotentD2-likeantagoNIST.Also5-HT1AagonistAlternativeNames:YM09151,YM09151-2ChemicalName:cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityHighlypotentdopamineD2-likereceptorantagonist;selectiveoverD1-likereceptors(Kivaluesare0.1and740nMforD2-likeandD1-likereceptorsrespectively).Alsopotent5-HT1Areceptoragonist(IC50=34nM)andhasaffinityforsigmareceptors.CompoundLibrariesNemonaprideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt387.91FormulaC21H26ClN3O2StorageStoreatRTPurity≥99%(HPLC)CASNumber75272-39-8PubChemID76968489InChIKeyQCYCDKUNJFKYEI-ZVWWNKPMSA-NSmilesO=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4CThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO9.725ethanol7.7620PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight387.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.58mL12.89mL25.78mL5mM0.52mL2.58mL5.16mL10mM0.26mL1.29mL2.58mL50mM0.05mL0.26mL0.52mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Assieetal(1997)5-HT1Areceptoragonistpropertiesoftheantipsychotic,nemonapride:comparisonwithbromergurideandclozapine.Eur.J.Pharmacol.334141PMID:9369342Teraietal(1983)SelectivebindingofYM-09151-2,anewpotentneuroleptic,toD2-dopaminergicreceptors.Jpn.J.Pharmacol.33749PMID:6138453Ujikeetal(1996)[3H]YM-09151-2(nemonapride),apotentrADIoligandforbothsigma1andsigma2receptorsubtypes.Neuroreport71057PMID:8804051Keywords:Nemonapride,supplier,5-HT1A,agonists,potent,D2-like,dopamine,antagonists,SEROtonin,Receptors,Non-Selective,dopaminergic,YM09151,YM09151-2,YM,09151,YM,09151-2,Non-selective,Dopamine,5-HT1A,Receptors,Non-selective,Dopamine,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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