Description:Highlypotent5-HT1AagoNIST;displaysuniquebindingmechanismChemicalName:4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamidehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityHighlypotentselective5-HT1Areceptorfullagonist(pKivaluesare9.0,6.6,7.5,6.6and<6.0for5-HT1A,5-HT1B,5-HT1C,5-HT2and5-HT3receptorsrespectively).PossIBLybindsbetweentheagonistbindingsiteandtheGproteininteractionswitchsite,affectingtheactivationmechanism,andmaydisplaypositivecooperativity.Anxiolyticfollowingcentraladministrationinvivo.CompoundLibrariesS14506hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt443.94FormulaC24H26FN3O2.HClStorageDesiccateatRTPurity≥99%(HPLC)CASNumber286369-38-8PubChemID131905InChIKeyHWLZKPKZVOLFGK-UHFFFAOYSA-NSmilesCl.COC1=CC2=C(C=CC=C2C=C1)N1CCN(CCNC(=O)C2=CC=C(F)C=C2)CC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO40.75100ethanol4.0710PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight443.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.25mL11.26mL22.53mL5mM0.45mL2.25mL4.51mL10mM0.23mL1.13mL2.25mL50mM0.05mL0.23mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Limaetal(1997)Atypicalinvitroandinvivobindingof[3H]S-14506tobrain5-HT1Areceptors.J.NeuralTransm.1041059PMID:9503258Milliganetal(2001)S14506:novelreceptorcouplingat5-HT1Areceptors.Neuropharmacology40334PMID:11166326Colpaertetal(1992)S14506:anovel,potent,high-efficacy5-HT1Aagonistandpotentialanxiolyticagent.DrugDev.Res.2621PMID:Keywords:S14506hydrochloride,supplier,potent,5-HT1A,agonists,SEROtonin,Receptors,S14506,hydrochloride,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
