Description:5-HT1A/1B/1DreceptoragoNISTAlternativeNames:GR43175ChemicalName:3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamidesuccinatePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivity5-HT1receptoragonist(Kivaluesare17,27and100nMat5-HT1D,5-HT1Band5-HT1Areceptorsrespectively).Antimigraineagent.CompoundLibrariesSumatriptansuccinateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt413.49FormulaC14H21N3O2S.C4H6O4StorageStoreat+4°CPurity≥99%(HPLC)CASNumber103628-48-4PubChemID59772InChIKeyPORMUFZNYQJOEI-UHFFFAOYSA-NSmilesO=S(CC1=CC=C(NC=C2CCN(C)C)C2=C1)(NC)=O.O=C(CCC(O)=O)OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO31.0175water41.35100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight413.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.42mL12.09mL24.18mL5mM0.48mL2.42mL4.84mL10mM0.24mL1.21mL2.42mL50mM0.05mL0.24mL0.48mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.PeroutkaandMcCarthy(1989)Sumatriptan(GR43175)interactsselectivitywith5-HT1Band5-HT1Dbindingsites.Eur.J.Pharmacol.163133PMID:2545459Peroutka(1990)Sumatriptaninacutemigraine:pharmacologyandreviewofworldexperience.Headache30554PMID:2177047Ottanietal(2004)Effectofsumatriptanindifferentmodelsofpaininrats.Eur.J.Pharmacol.497181PMID:15306203Keywords:Sumatriptansuccinate,supplier,5-HT1,receptor,agonists,Non-Selective,SEROtonin,Receptors,GR43175,GR,43175,5-HT1A,Receptors,5-HT1B,Receptors,5-HT1D,Receptors,5-HT1D,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
