产品说明
Description:Selective5-HT1ApartialagoNISTAlternativeNames:SM-3997ChemicalName:(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivity5-HT1Areceptorpartialagonist(Ki=27nM)thatdisplaysselectivityover5-HT2,5-HT1C,α1,α2,D1andD2receptors(Kivaluesrangingfrom1300-41000nM).Inactiveat5-HTuptakesites,5-HT1B,β-adrenergic,muscarinicandbenzodiazepinereceptors.Displaysanxiolyticactivity.CompoundLibrariesTandospironehydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt419.95FormulaC21H29N5O2.HClStorageStoreat+4°CPurity≥98%(HPLC)CASNumber99095-10-0PubChemID13422623InChIKeyACVFJYKNBOHIMH-DPFKZJTMSA-NSmiles[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO41.99100water41.99100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight419.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.38mL11.91mL23.81mL5mM0.48mL2.38mL4.76mL10mM0.24mL1.19mL2.38mL50mM0.05mL0.24mL0.48mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Hamiketal(1990)Analysisoftandospirone(SM-3997)interactionswithneurotransmitterreceptorbindingsites.Biol.Psychiatry2899PMID:1974152Pollardetal(1992)Effectsoftandospironeinthreebehavioraltestsforanxiolytics.Eur.J.Pharmacol.221297PMID:1358655Matsubaraetal(2006)Tandospirone,a5-HT1Aagonist,amelioratesmovementdisordervianon-dopaminergicsystemsinratswithunilateral6-hydroxydopamine-generatedlesions.BrainRes.1112126PMID:16884702Keywords:Tandospironehydrochloride,supplier,Selective,5-HT1A,partial,agonists,SEROtonin,Receptors,SM3997,SM-3997,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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