Description:Potent5-HT1ApartialagoNISTandSSRI;antidepressantAlternativeNames:EMD68843,SB659746AChemicalName:5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamidehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent5-HT1ApartialagonistandSEROtonin-selectivereuptakeinhibitor(SSRI)(IC50valuesare0.2and0.5nMrespectively).Antidepressant.TechnicalDataM.Wt477.99FormulaC26H27N5O2.HClStorageStoreat-20°CPurity≥98%(HPLC)CASNumber163521-08-2PubChemID6918313InChIKeyRPZBRGFNBNQSOP-UHFFFAOYSA-NSmilesNC(C1=CC2=C(C=CC(N3CCN(CC3)CCCCC4=CNC5=C4C=C(C#N)C=C5)=C2)O1)=O.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO9.5620PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight477.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.09mL10.46mL20.92mL5mM0.42mL2.09mL4.18mL10mM0.21mL1.05mL2.09mL50mM0.04mL0.21mL0.42mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Hughesetal(2005)NeuRochemicalevaluationofthenovel5-HT1Areceptorpartialagonist/serotoninreuptakeinhibitor,vilazodone.Eur.J.Pharmacol.51049PMID:15740724Keywords:Vilazodonehydrochloride,supplier,SB659746A,EMD68843,Potent,5-HT1A,partial,agonists,agonism,serotonin-selective,reuptake,inhibitors,inhibits,SSRI,antidepressant,EMD,68843,SB,659746A,5-HT1A,Receptors,5-HT,Transporters,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
