产品说明
Description:Orallyactive,highaffinity5-HT1AagoNISTAlternativeNames:SR57746AChemicalName:1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridinehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityOrallyactive,fullagonistat5-HT1Areceptors.Bindsrat5-HT1Awithhighaffinity(Ki=2.0nM)andis>300-foldselectiveoverother5-HTreceptorsubtypes(IC50>650nM).IncreasesmotoneuronsurvivalandpromoteseffectsofNGFonneuriteoutgrowthinvitro.Displaysneurotrophicactivityinseveralneurodegenerativemodelsinvivo. .CompoundLibrariesXaliprodenhydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt417.9FormulaC24H22F3N.HClStorageDesiccateatRTPurity≥99%(HPLC)CASNumber90494-79-4PubChemID128918InChIKeyWVHBEIJGAINUBW-UHFFFAOYSA-NSmilesCl.FC(F)(F)C1=CC(=CC=C1)C1=CCN(CCC2=CC=C3C=CC=CC3=C2)CC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO41.79100ethanol8.3620PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight417.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.39mL11.96mL23.93mL5mM0.48mL2.39mL4.79mL10mM0.24mL1.2mL2.39mL50mM0.05mL0.24mL0.48mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Fournieretal(1993)ProtectiveeffectsofSR57746Aincentralandperipheralmodelsofneurodegenerativedisordersinrodentsandprimates.Neuroscience55629PMID:8413926Duongetal(1999)EffectofthenonpeptideneurotrophiccompoundSR57746Aonthephenotypicsurvivalofpurifiedmousemotoneurons.Br.J.Pharmacol.1281385PMID:10602316Bachyetal(1993)BiochemicalandelectrophysiologicalpropertiesofSR57746A,anew,potent5-HT1Areceptoragonist.Fund.Clin.Pharmacol.7487PMID:Keywords:Xaliprodenhydrochloride,supplier,Orally,active,high,affinity,5-HT1A,agonists,SEROtonin,Receptors,SR57746A,SR,57746A,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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