Description:5-HT1A/1BantagoNIST.Alsoβ-adrenergicantagonistChemicalName:4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrilehemifumaratePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivity5-HT1A/1Bantagonistwithroughlyequalaffinityateachreceptor;alsoaβ-adrenoceptorantagonist.TechnicalDataM.Wt345.4FormulaC16H21N3O2.½C4H4O4StorageStoreatRTPurity≥98%(HPLC)CASNumber69906-86-1PubChemID45073413InChIKeyZSBITJKBOWVCCI-WXXKFALUSA-NSmiles[H]OC(=O)C=CC(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#NThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO34.54100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight345.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.9mL14.48mL28.95mL5mM0.58mL2.9mL5.79mL10mM0.29mL1.45mL2.9mL50mM0.06mL0.29mL0.58mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Engeletal(1986)Identityofpresynaptic5-hydroxytryptamine(5-HT)autoreceptorsintheratbraincortexwith5-HT1Bbindingsites.NaunynSchmiedebergsArch.Pharmacol.3321PMID:2936965Gilesetal(1996)Characterizationofa5-HT1BreceptoronCHOcells:functionalresponsesintheabsenceofrADIoligandbinding.Br.J.Pharmacol.1171119PMID:8882605Hoeyetal(1996)Atypicalresponsesofratileumtopindolol,cyanopindololandiodocyanopindolol.Br.J.Pharmacol.117712PMID:8646418Blueetal(1989)Interactionofdihydroalprenololandcyanopindololwithatypicalβ-adrenoceptorsinguinea-pigileum.Br.J.Pharmacol.96246PPMID:Keywords:Cyanopindololhemifumarate,supplier,5-HT1A/1B,antagonists,β-adrenergic,beta-adrenergic,β-adrenoceptor,beta-adrenoceptor,b-adrenergic,b-adrenoceptor,SEROtonin,5-HT1A,Receptors,5-HT1A,Receptors,5-HT1B,Receptors,Non-selective,Adrenergic,Beta,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
