Description:Selective,highaffinity5-HT1AantagoNISTChemicalName:(3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamidehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivitySelective,highaffinity5-HT1Areceptorantagonist(Ki=0.6nMinvitro).Enhancestheactionofselective5-HTreuptakeinhibitorsandreversescitalopram-induced(Cat.No.1427)inhibitionofSEROtonergiccellfiring.LicensingInformationSoldforresearchpurposesunderagreementfromAstraZenecaCompoundLibrariesNAD299hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt354.85FormulaC18H23FN2O2.HClStorageDesiccateatRTPurity≥98%(HPLC)CASNumber184674-99-5PubChemID90488823InChIKeyGSZJANKLCPHEEX-BTQNPOSSSA-NSmilesFC1=C2C(C[C@@H](N(C4CCC4)C3CCC3)CO2)=C(C(N)=O)C=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO35.48100water35.48100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight354.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.82mL14.09mL28.18mL5mM0.56mL2.82mL5.64mL10mM0.28mL1.41mL2.82mL50mM0.06mL0.28mL0.56mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Larssonetal(1998)Differentialregionalantagonismof8-OH-DPAT-induceddecreaseinserotoninsynthesisbytwo5-HT1Areceptorantagonists.Eur.J.Pharmacol.346209PMID:9652362Arboreliusetal(1999)The5-HT1Areceptorantagonistrobalzotancompletelyreversescitalopram-inducedinhibitionofserotonergiccellfiring.Eur.J.Pharmacol.382133PMID:10528148Johanssonetal(1997)Thepharmacologicalcharacterizationofanovelselective5-hydroxytryptamine-1Areceptorantagonist,NAD-299.J.Pharamacol.Exp.Ther.283216PMID:Keywords:NAD299hydrochloride,supplier,AstraZeneca,5-HT1A,serotonin,5-HT,receptor,antagonists,NAD299,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
