Description:β-adrenoceptorantagoNIST.Also5-HT1A/1BantagonistChemicalName:4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylicacid,1-methylethylesterBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityβ-adrenoceptorand5-HT1A/1Breceptorantagonist.pKB/pA2valuesare8.3and8.0for5-HT1Aand5-HT1Breceptorsrespectively.Centrallyactivefollowingsystemicadministrationinvivo.TechnicalDataM.Wt348.44FormulaC19H28N2O4StorageStoreatRTCASNumber39731-05-0PubChemID193949InChIKeySJYFDORQYYEJLB-UHFFFAOYSA-NSmilesCC(C)OC(=O)C1=CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO34.84100ethanol34.84100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight348.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.87mL14.35mL28.7mL5mM0.57mL2.87mL5.74mL10mM0.29mL1.43mL2.87mL50mM0.06mL0.29mL0.57mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Chojnacka-WojcikandPrzegalinski(1991)Evidencefortheinvolvementof5-HT1Areceptorsintheanticonflicteffectofipsapironeinrats.Neuropharmacology30703PMID:1681448Hoyeretal(1994)VIIInternationalUnionofPharmacologyclassificationofreceptorsfor5-hydroxytryptamine(SEROtonin).Pharmacol.Rev.46157PMID:7938165Engeletal(1986)Identityofinhibitorypresynaptic5-hydroxytryptamine(5-HT)autoreceptorsintheratbraincortexwith5-HT1Bbindingsites.Naunyn-Schmied.Arch.Pharmacol.3321PMID:Keywords:SDZ21009,supplier,β-adrenoceptor,beta-adrenoceptor,b-adrenoceptor,antagonists,5-HT1A/1B,β-adrenergic,beta-adrenergic,b-adrenergic,Receptors,Non-Selective,Serotonin,SDZ21009,Non-selective,Adrenergic,Beta,Receptors,5-HT1A,Receptors,5-HT1B,Receptors,Non-selective,Adrenergic,Beta,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
