Description:Potentα2CantagoNISTChemicalName:8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-oneBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivity5-HT1Aantagonist.Moreactiveandselectivethanspiperone.Alsoaverypotentα2Cadrenergicreceptorantagonist.TechnicalDataM.Wt379.46FormulaC22H25N3O3StorageStoreatRTCASNumber1054-88-2PubChemID5268InChIKeyJVGBTTIJPBFLTE-UHFFFAOYSA-NSmilesO=C1NCN(C2=CC=CC=C2)C11CCN(CC2COC3=CC=CC=C3O2)CC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO3.7910PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight379.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.64mL13.18mL26.35mL5mM0.53mL2.64mL5.27mL10mM0.26mL1.32mL2.64mL50mM0.05mL0.26mL0.53mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysisiscurrentlyunavailableon-line.PleasecontactCustomerServiceSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Bylundetal(1992)Pharmacologicalcharacteristicsofα2-adrenergicreceptors:comparisonofpharmacologicallydefinedsubtypeswithsubtypesidentifiedbymolecularcloning.Mol.Pharmacol.421PMID:1353247NelsonandTaylor(1986)Spiroxatrine:aselectiveSEROtonin1Areceptorantagonist.Eur.J.Pharmacol.124207PMID:3720840SchoeffterandHoyer(1988)Centrallyactinghypotensiveagentswithaffinityfor5-HT1Abindingsitesinhibitforskolin-stimulatedadenylatecyclaseactivityincalfhippocampus.Br.J.Pharmacol.95975PMID:3207999Keywords:Spiroxatrine,supplier,Potent,α2C-adrenoceptor,alpha2C-adrenoceptor,alpah4c-adrenergic,a2c-adrenoceptor,a2c-adrenergic,antagonists,5-HT1A,Receptors,Serotonin,Adrenergic,Alpha-2,Receptors,5-HT1A,Receptors,Adrenergic,Alpha-2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
