产品说明
Description:Potent,selective5-HT1AantagoNISTChemicalName:(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamidedihydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent,selective5-HT1Areceptorantagonist(IC50=15nM).Selectiveover5-HT1B,1C,2,α1,α2andD2receptors(IC50>1000nM).Centrallyactiveonsystemicadministration.LicensingInformationSoldwiththepermissionofWyeth-AyerstResearch,USPatent4,988,814TechnicalDataM.Wt468.47FormulaC24H33N3O2.2HClStorageDesiccateat+4°CPurity≥99%(HPLC)CASNumber149007-54-5PubChemID6604839InChIKeyNYZFUZCCDOSQBG-AWEZNQCLSA-NSmilesO=C(NC(C)(C)C)[C@@]([C@]3=CC=CC=C3)([H])CN(CC2)CCN2C1=C(OC)C=CC=C1.Cl.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO46.85100water2.345mMwithgentlewarmingwater4.6810mMwithsonicationPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight468.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.13mL10.67mL21.35mL5mM0.43mL2.13mL4.27mL10mM0.21mL1.07mL2.13mL50mM0.04mL0.21mL0.43mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Cliffeetal(1993)(S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide[(S)-WAY-100135]:aselectiveantagonistatpresynapticandpostsynaptic5-HT1Areceptors.J.Med.Chem.361509PMID:8496920Fletcheretal(1993)WAY100135:anovel,selectiveantagonistatpresynapticandpostsynaptic5-HT1Areceptors.Eur.J.Pharmacol.237283PMID:8365456Fletcheretal(1993)Silent5-HT1Areceptorantagonists:utilityasresearchtoolsandtherapeuticagents.TrendsPharmacol.Sci.1441PMID:8122313RodgersandCole(1994)Anxiolytic-likeeffectof(S)-WAY100135,a5-HT1Areceptorantagonist,inthemurineelevatedplus-mazetest.Eur.J.Pharmacol.261321PMID:7813555Keywords:(S)-WAY100135dihydrochloride,supplier,Potent,selective,5-HT1A,antagonist,SEROtonin,Receptors,(S)-WAY100135,dihydrochloride,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
新品排行榜
1
Tocris/Cardamonin/2509/10/10 mg
2
Tocris/TG 100713/4264/10/10 mg
3
Tocris/SB 3CT/6088/10/10 mg
4
Tocris/rac BHFF/3313/50/50 mg
5
Tocris/Cardamonin/2509/50/50 mg
6
Tocris/BAM 15/5737/50/50 mg
7
Tocris/PF 04217903 mesylate/4239...
8
Tocris/α-Amanitin/4025/1/1 ...
9
Tocris/GBR 12783 dihydrochloride...
10
Tocris/BAM 7/4810/10/10 mg
文章排行榜
1
novus抗体-价格-采购-供应商信息-丁香通
2
Tocris/(RS)-3-Hydroxyphenylglycine/0324/50/50 mg
3
Tocris/SCH 442416/2463/10/10 mg
4
Tocris Bioscience部分产品7.5折促销
5
小分子 | Tocris 生物科学,tocris产品目录
6
Tocris/VUF 11207 fumarate/4780/50/50 mg
7
Tocris/CGP 54626 hydrochloride/1088/10/10 mg
8
Tocris/JNJ 10181457 dihydrochloride/4019/10/10 mg
9
Tocris/VUF 11222/5668/10/10 mg
10
关于 Tocris | Tocris 生物科学,Tocris/SB 265610/2724/1/1 mg
