Description:Potent,5-HT1AsilentantagoNIST.AlsoD4agonistChemicalName:N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamidemaleatePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent,silentantagonistof5-HT1Areceptors(IC50=2.2nM;Ki=0.84nMforrat5-HT1Areceptors).Displays100-foldselectivityfor5-HT1Aoverother5-HTsubtypes.AlsoexhibitsagonistactivityatdopamineD4receptors.TechnicalDataM.Wt538.64FormulaC25H34N4O2.C4H4O4StorageDesiccateatRTPurity≥99%(HPLC)CASNumber634908-75-1PubChemID11957721InChIKeyXIGAHNVCEFUYOV-BTJKTKAUSA-NSmilesO=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(C=C/C(O)=O)OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilitywater13.4725PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight538.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.86mL9.28mL18.57mL5mM0.37mL1.86mL3.71mL10mM0.19mL0.93mL1.86mL50mM0.04mL0.19mL0.37mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Mensonides-Harsemaetal(2000)Synthesisandinvitroandinvivofunctionalstudiesofortho-substitutedphenylpiperazineandN-substituted4-N-(o-methoxyphenyl)aminopiperidineanaloguesofWAY100635.J.Med.Chem.43432PMID:10669570Zhuangetal(1994)Synthesisandevaluationof4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine(p-MPPI):anewiodinated5-HT1Aligand.J.Med.Chem.371406PMID:8182697Forsteretal(1995)Apharmacologicalprofileoftheselectivesilent5-HT1Areceptorantagonist,WAY-100635.Eur.J.Pharmacol.28181PMID:8566121Chemeletal(2006)WAY-100635isapotentdopamineD4receptoragonist.Psychopharmacology(Berl).188244PMID:16915381Keywords:WAY100635maleate,supplier,WAY100635,5-ht1a,SEROtonin,serotonergics,selective,antagonists,dopamine,D4,antagonists,dopaminergics,5-HT1A,Receptors,D4,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
