Description:Potent5-HT1AligandChemicalName:8-[4-(1,4-Benzodioxan-2-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dionehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityApotentligandat5-HT1Areceptors,withmixedagoNISTandantagonistproperties.Anagonistatpost-synaptic5-HT1Areceptors.TechnicalDataM.Wt422.95FormulaC22H30N2O4.HClStorageStoreatRTPurity≥99%(HPLC)CASNumber113777-40-5PubChemID45073438InChIKeyGQGDGISNRPBRSG-UHFFFAOYSA-NSmilesCl.O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COC2=CC=CC=C2O1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolubilitySolubleto5mMinwaterPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight422.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.36mL11.82mL23.64mL5mM0.47mL2.36mL4.73mL10mM0.24mL1.18mL2.36mL50mM0.05mL0.24mL0.47mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Millanetal(1993)Inductionofhypothermiaasamodelof5-hydroxytryptamine1Areceptor-mediatedactivityintherat-apharmacologicalcharacterizationoftheactionsofnovelagonistsandantagonists.J.Pharmacol.Exp.Ther.2641364PMID:8450471Miretal(1988)MDL72832:apotentandstereoselectiveligandatcentralandperipheral5-HT1Areceptors.Eur.J.Pharmacol.149107PMID:2840295Keywords:MDL72832hydrochloride,supplier,Potent,5-HT1A,ligand,SEROtonin,Receptors,5-HT1,MDL72832,hydrochloride,5-HT1A,Receptors,5-HT1A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
