Description:CB2selectiveantagoNIST/inverseagonistChemicalName:6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanonePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityCB2antagonist/inverseagonist(Ki=31.2nM)thatdisplays165-foldselectivityoverCB1receptors.Behavesasaweakpartial/inverseagonistatCB1receptors.TechnicalDataM.Wt504.37FormulaC23H25IN2O3StorageDesiccateat+4°CPurity≥98%(HPLC)CASNumber164178-33-0PubChemID4302963InChIKeyJHOTYHDSLIUKCJ-UHFFFAOYSA-NSmilesCOC1=CC=C(C=C1)C(=O)C1=C(C)N(CCN2CCOCC2)C2=CC(I)=CC=C12Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO50.44100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight504.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.98mL9.91mL19.83mL5mM0.4mL1.98mL3.97mL10mM0.2mL0.99mL1.98mL50mM0.04mL0.2mL0.4mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Hosohataetal(1997)AM630isacompetitivecannABInoidreceptorantagonistintheguineapigbrain.LifeSci.61PL115PMID:9284087Hosohataetal(1997)AM630antagonismofcannabinoid-stimulated[35S]GTPγSbindinginthemousebrain.Eur.J.Pharmacol.321R1PMID:9083796Landsmanetal(1998)AM630isaninverseagonistatthehumancannabinoidCB1receptor.LifeSci.62PL109PMID:9496703Rossetal(1999)Agonist-inverseagonistcharacterizationatCB1andCB2cannabinoidreceptorsofL759633,L759656andAM630.Br.J.Pharmacol.126665PMID:10188977Keywords:AM630,supplier,CB2,selective,antagonists,inverse,agonists,Cannabinoids,Receptors,AM630,cb2r,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
