首页 > Tocris > Tocris/Anandamide (in Tocrisolve™ 100)/1017/50/50 mg

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Tocris/Anandamide (in Tocrisolve™ 100)/1017/50/50 mg

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Description:EndogenousCBreceptoragoNIST(inwater-solubleemulsion)AlternativeNames:Arachidonylethanolamide,AEAChemicalName:N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamideBIOLOGicalActivityTechnicalDataDatasheetsReferencesBiologicalActivityEndogenouscannABInoidandvanilloidreceptoragonist,inwater-solubleemulsion(fordetailsseeTocrisolveTM100,Cat.No.1684).Kivaluesare89and371nMforCB1andCB2receptorsrespectively;EC50valuesare18,31and27nMatGPR55,CB1andCB2respectively;pKi=5.68forrVR1.AlsoblocksTNF-α-inducedNF-kBactivationviadirectinhibitionofIKK.Alsoavailableasthepureoildissolvedinethanol(Anandamine,Cat.No.1339).TocrisolveControl(Cat.No.1684)alsoavailable.TechnicalDataM.Wt347.54FormulaC22H37NO2StorageStoreat+4°CCASNumber94421-68-8PubChemID5281969InChIKeyLGEQQWMQCRIYKG-DOFZRALJSA-NSmilesO=C(NCCO)CCCC=C/CC=C/C/C=CC/C=CCCCCCThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight347.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.88mL14.39mL28.77mL5mM0.58mL2.88mL5.75mL10mM0.29mL1.44mL2.88mL50mM0.06mL0.29mL0.58mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Gardineretal(2002)Complexregionalhaemodynamiceffectsofanandamideinconsciousrats.Br.J.Pharmacol.1351889PMID:11959791Kagayaetal(2002)Characterizationoftheanandamide-induceddepolarizationofguinea-pigisolatedvagusnerve.Br.J.Pharmacol.13739PMID:12183329Pertwee(1999)Pharmacologyofcannabinoidreceptorligands.Curr.Med.Chem.6635PMID:10469884Rossetal(2001)Structure-activityrelationshipfortheendogenouscannabinoid,anandamide,andcertainofitsanaloguesatvanilloidreceptorsintransfectedcellsandvasdeferens.Br.J.Pharmacol.132631PMID:11159715Rybergetal(2007)TheorphanreceptorGPR55isanovelcannabinoidreceptor.Br.J.Pharmacol.1521092PMID:17876302Sanchoetal(2003)Anandamideinhibitsnuclearfactor-κBactivationthroughacannabinoidreceptor-independentpathway.Mol.Pharmacol.63429PMID:12527815Keywords:Anandamide(inTocrisolve100),supplier,Endogenous,CB,agonist,water-soluble,emulsion,vanilloid,Cannabinoids,Non-Selective,Receptors,Vanillioid,VR1,TRPV,TRP,Channels,Transient,Receptor,Potential,cb2r,cb1r,Arachidonylethanolamide,AEA,Non-selective,Cannabinoids,TRPV,Non-selective,Cannabinoids,TocrisBioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins