Description:CB1/CB2receptorpartialagoNISTChemicalName:3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl4,4,4-trifluoro-1-butanesulfonicacidesterPurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityNovelCB1/CB2receptorpartialagonist(Kivaluesare48.3and45.5nMathumanCB1andCB2receptorsrespectively).OrallyactiveCB1agonistinvivo.Displaysanti-hyperalgesicandantiallodynicpropertiesinratmodelsofchronicneuropathicandinflammatorypain.LicensingInformationSoldforresearchpurposesunderagreementfromBayerTechnicalDataM.Wt453.35FormulaC18H13F6NO4SStorageStoreat+4°CPurity≥99%(HPLC)CASNumber406205-74-1PubChemID10479060InChIKeyLWUSZIVDPJPVBW-UHFFFAOYSA-NSmilesFC(F)(F)CCCS(=O)(=O)OC1=CC(OC2=CC=CC(=C2C#N)C(F)(F)F)=CC=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO45.34100ethanol45.34100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight453.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.21mL11.03mL22.06mL5mM0.44mL2.21mL4.41mL10mM0.22mL1.1mL2.21mL50mM0.04mL0.22mL0.44mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.DeVryetal(2004)3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate(BAY59-3074):anovelcannABInoidCB1/CB2receptorpartialagonistwithantihyperalgesicandantiallodyniceffects.J.Pharmacol.Exp.Ther.310620PMID:15140913DeVryetal(2004)DiscriminativestimuluseffectsofthestructurallynovelcannabinoidCB1/CB2receptorpartialagonistBAY59-3074intherat.EurJPharmacol.505127PMID:15556145Keywords:Bay59-3074,supplier,CB1/CB2,receptor,partial,agonists,cannabinoids,Non-Selective,Receptors,Bay59-3074,cb2r,cb1r,Non-selective,Cannabinoids,Non-selective,Cannabinoids,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
