Description:PotentdualCB1/CB2agoNISTChemicalName:1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanonePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent,orallyactiveCB1/CB2receptoragonistwithlimitedbrainpenetration(EC50valuesare6.1and27.9nMforCB1andCB2receptorsrespectively).DisplaysantihyperalgesicactivityinaratmodelofneuropathicpainwithnoCNSsideeffects.TechnicalDataM.Wt368.47FormulaC26H24O2StorageStoreatRTPurity≥99%(HPLC)CASNumber432047-72-8PubChemID9799417InChIKeyRSUMDJRTAFBISX-UHFFFAOYSA-NSmilesO=C(C3=CC=CC4=C3C=CC=C4)C2=CC=C(OCCCCC)C1=CC=CC=C12Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO36.85100ethanol18.4250PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight368.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.71mL13.57mL27.14mL5mM0.54mL2.71mL5.43mL10mM0.27mL1.36mL2.71mL50mM0.05mL0.27mL0.54mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Dziadulewiczetal(2007)Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:apotent,orallybioavailablehumanCB1/CB2dualagonistwithantihyperalgesicpropertiesandrestrictedcentralnervoussystempenetration.J.Med.Chem.503851PMID:17630726Clunyetal(2010)Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone(SAB378),aperipherallyrestrictedcannABInoidCB1/CB2receptoragonist,inhibitsgastrointestinalmotilitybuthasnoeffectonexperimentalcolitisinmice.J.Pharmacol.Exp.Ther.334973PMID:20571060Keywords:CB13,supplier,Potent,dual,CB1/CB2,agonists,cannabinoids,Non-Selective,Receptors,CB13,cb2r,cb1r,Non-selective,Cannabinoids,Non-selective,Cannabinoids,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
