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Tocris/CP 55,940/0949/50/50 mg

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Description:Potent,non-selectivecannABInoidreceptoragoNISTChemicalName:(-)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanolPurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityCannabinoidagonistwhichisconsiderablymorepotentthanΔ9-THCinbothbehavioraltestsandreceptorbindingassays.Displayshighandroughlyequalaffinityforbothcentralandperipheralcannabinoidreceptors(Ki=0.6-5.0and0.7-2.6nMatCB1andCB2respectively;EC50valuesare0.2,0.3and5nMatCB1,CB2andGRP55respectively).LicensingInformationSoldforresearchpurposesunderagreementfromPfizerInc.TechnicalDataM.Wt376.58FormulaC24H40O3StorageStoreat-20°CPurity≥98%(HPLC)CASNumber83002-04-4PubChemID104895InChIKeyYNZFFALZMRAPHQ-SYYKKAFVSA-NSmilesO[C@H]1C[C@@H]([C@]2=CC=C(C(C)(C)CCCCCC)C=C2O)[C@H](CCCO)CC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO37.66100ethanol37.66100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight376.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.66mL13.28mL26.55mL5mM0.53mL2.66mL5.31mL10mM0.27mL1.33mL2.66mL50mM0.05mL0.27mL0.53mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Griffinetal(1998)Evaluationofcannabinoidreceptoragonistsandantagonistsusingtheguanosine-5'-O-(3-[35S]thio)-triphosphatebindingassayinratcerebellarmembranes.J.Pharmacol.Exp.Ther.285553PMID:9580597Thomasetal(1998)Comparativereceptorbindinganalysesofcannabinoidagonistsandantagonists.J.Pharmacol.Exp.Ther.285285PMID:9536023Wileyetal(1995)DiscriminativestimuluseffectsofCP55,940andstructurallydissimilarcannabinoidsinrats.Neuropharmacology34669PMID:7566504Avdesh(2011)Corticosteroiddependentandindependenteffectsofacannabinoidagonistoncoretemperature,motoractivity,andprepulseinhibitionoftheacousticstartlereflexinWistarrats.PsychopharmacologyEpubaheadofprintPMID:21947354Keywords:CP55,940,supplier,Potent,non-selective,cannabinoids,receptors,agonists,Non-Selective,CP55940,cb2r,cb1r,Pfizer,Non-selective,Cannabinoids,Non-selective,Cannabinoids,TocrisBioscience

Tocris Bioscience.png

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins