产品说明
Description:Mixed5-HT2A/2CagoNISTAlternativeNames:(±)-2,5-Dimethoxy-4-iodoamphetaminehydrochlorideChemicalName:4-Iodo-2,5-dimethoxy-α-methylbenzeneethanaminehydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityBrainpenetrant,mixed5-HT2A/5-HT2Creceptoragonist(Kivaluesare0.7,2.4and20nMfor5-HT2A,5-HT2Cand5-HT2Breceptorsrespectively).Reducesrapideyemovement(REM)andslowwavesleepandincreaseswakingintherat.Hallucinogenicagent.Actsvia5-HT2Areceptorstoinhibittheinflammatoryeffectsoftumornecrosisfactor(TNF)-α.TechnicalDataM.Wt357.62FormulaC11H16INO2.HClStorageStoreatRTPurity≥98%(HPLC)CASNumber42203-78-1PubChemID170617InChIKeyQVFDMWGKHUFODK-UHFFFAOYSA-NSmilesIC1=C(OC)C=C(CC(C)N)C(OC)=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilitywater17.8850PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight357.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.8mL13.98mL27.96mL5mM0.56mL2.8mL5.59mL10mM0.28mL1.4mL2.8mL50mM0.06mL0.28mL0.56mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.MontiandJantos(2006)EffectsofSEROtonin5-HT2A/2CreceptoragonistDOIandoftheselective5-HT2Aor5-HT2CreceptorantagonistsEMD281014andSB-243213respectively,onsleepandwakingintherat.Eur.J.Pharmacol.553163PMID:17059817Yuetal(2008)Serotonin5-hydroxytryptamine2Areceptoractivationsuppressestumornecrosisfactor-α-inducedinflammationwithextraordinarypotency.J.Pharmacol.Exp.Ther.327316PMID:18708586Nelsonetal(1999)Comparisonsofhallucinogenicphenylisopropylaminebindingaffinitiesatclonedhuman5-HT2A,5-HT2Band5-HT2Creceptors.Naunyn-Schmied.Arch.Pharmacol.3591PMID:Keywords:DOIhydrochloride,supplier,Mixed,5-H2A,5-HT2C,agonists,serotonin,receptors,5-hydroxytryptamine,(±)-2,5-Dimethoxy-4-iodoamphetamine,hydrochloride,5-HT2A,Receptors,5-HT2C,Receptors,5-HT2A,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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