Description:5-HT2CantagoNISTAlternativeNames:Normethylclozapine,NorclozapineChemicalName:8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepinePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityAmajormetaboliteofclozapine;apotentandselective5-HT2CSEROtoninreceptorantagonist.TechnicalDataM.Wt312.8FormulaC17H17ClN4StorageStoreatRTPurity≥99%(HPLC)CASNumber6104-71-8PubChemID210172InChIKeyNIBOMXUDFLRHRV-UHFFFAOYSA-NSmilesClC1=CC=C2NC3=C(C=CC=C3)C(=NC2=C1)N1CCNCC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO31.28100ethanol31.28100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight312.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.2mL15.98mL31.97mL5mM0.64mL3.2mL6.39mL10mM0.32mL1.6mL3.2mL50mM0.06mL0.32mL0.64mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.FoxandBrotchie(1996)Normethylclozapinepotentiatestheactionofquinpiroleinthe6-hydroxydopaminelesionedrat.Eur.J.Pharmacol.30127PMID:8773443Kuoppamäkietal(1993)Clozapineandmethylclozapinearepotent5-HT1Creceptorantagonists.Eur.J.Pharmacol.245179PMID:8387927Wongetal(1996)EffectsofclozapinemetabolitesandchronicclozapinetreatmentonratbrainGABAAreceptors.Eur.J.Pharmacol.314319PMID:8957253Keywords:N-Desmethylclozapine,supplier,5-HT2C,antagonists,Serotonin,Receptors,Norclozapine,Normethylclozapine,Norclozapine,5-HT2C,Receptors,5-HT2C,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌,其产品也广为各大药厂、大学、研究机构,超过五万名科学研究者所采用。 目前,產品內容已超過一千六百種以上,並每年持續不斷的增加新的產品。目前,产品内容已超过一千六百种以上,并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔(Bristol)的高品质试剂提供商,共有2000多种产品,主要集中在神经科学和信号传导领域,产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等,主要产品包括GPCR ligands,神经传递素,离子通道调控剂,信号通路抑制剂等,这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者,其生产的影响神经系统的化学物质被多次引用,这些物质很多都来自Jeff Watkins(Tocris 的创立人)在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括:
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分:
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System