Description:5-HTre-uptakeinhibitor.Alsostimulates5-HTreleaseAlternativeNames:(+)-FenfluramineChemicalName:(S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanaminehydrochlorideBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityIndirectlyagonizesSEROtoninreceptorsviainhibitionof5-HTre-uptakeandstimulationof5-HTrelease.Anorecticagent;decreasesgrowthhormone,insulin,leptin,fatmass,leanmassandincreasesghrelinindiet-switcheddiet-inducedobesemice.TechnicalDataM.Wt267.72FormulaC12H16F3N.HClStorageDesiccateatRTCASNumber3239-45-0PubChemID66264InChIKeyZXKXJHAOUFHNAS-FVGYRXGTSA-NSmilesC[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO26.77100water26.77100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight267.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.74mL18.68mL37.35mL5mM0.75mL3.74mL7.47mL10mM0.37mL1.87mL3.74mL50mM0.07mL0.37mL0.75mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Cacciaetal(1997)Neuropharmacologicaleffectsoflowandhighdosesofrepeatedoraldexfenfluramineinrats:acomparisonwithfluoxetine.Pharmacol.Biochem.Behav.57851PMID:9259015Higginsetal(2001)Influenceofthe5-HT2CreceptorantagoNISTSB242,084onbehaviourproducedbythe5-HT2agonistRo60-0175andtheindirect5-HTagonistdexfenfluramine.Br.J.Pharmacol.133459PMID:11399662Bushetal(2006)Chronictreatmentwitheitherdexfenfluramineorsibutramineindiet-switcheddiet-inducedobesemice.Endocrine29375PMID:16785615Keywords:Dexfenfluraminehydrochloride,supplier,5-HT,reuptake,inhibitors,inhibits,stimulates,release,Serotonin,5-Hydroxytryptamine,Receptors,Transporters,SERT,Monoamine,Neurotransmitter,(+)-Fenfluramine,5-HT,Transporters,5-HT-Related,5-HT3,Receptors,5-HT,Transporters,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
