Description:HighlyselectiveCB2agoNISTChemicalName:N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityHighlyselectiveCB2receptoragonist;Kivaluesare0.037and363nMforCB2andCB1receptorsrespectively.IncreasesP-ERK1/2expressioninHL-60cellsinvitro.MorerecentlyshowntobeCB2receptorinverseagonist/antagonistincAMP,GTPγSandβ-arrestinrecruitmentassays.TechnicalDataM.Wt441.35FormulaC23H22Cl2N4OStorageStoreatRTPurity≥99%(HPLC)CASNumber511532-96-0PubChemID10252734InChIKeyFNOMTMVRTBHRET-UHFFFAOYSA-NSmilesCC1=CC2=C(C=C1)C1=C(C2)C(=NN1C1=CC=C(Cl)C=C1Cl)C(=O)NN1CCCCC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO44.13100ethanol44.13100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight441.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.27mL11.33mL22.66mL5mM0.45mL2.27mL4.53mL10mM0.23mL1.13mL2.27mL50mM0.05mL0.23mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Murinedduetal(2006)Tricyclicpyrazoles.4.SynthesisandbiologicalevaluationofanaloguesoftherobustandselectiveCB2cannABInoidligand1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamJ.Med.Chem.497502PMID:17149879Tschopetal(2009)Thecannabinoidreceptor2iscriticalforthehostresponsetosepsis.J.Immunol.183499PMID:19525393Soethoudtetal(2017)CannabinoidCB2receptorligandprofilingrevealsbiasedsignallingandoff-targetactivity.Nat.Commun.PMID:28045021Keywords:GP1a,supplier,selective,CB2,receptor,agonists,cannabinoid,receptors,GP1a,cb2r,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
