Description:PotentandselectiveTRPV4antagoNISTChemicalName:2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectiveTRPV4antagonist.ReversIBLyinhibitscurrentsthroughmouse,humanandratTRPV4orthologs(IC50valuesare17,48and133nMrespectively).AlsoinhibitstheendogenousTRPV4-mediatedresponseto4α-PDH(IC50=22nM).SelectiveforTRPV4overTRPV1,TRPV2,TRPV3andTRPM8channels.TechnicalDataM.Wt471.51FormulaC26H28F3N3O2StorageStoreat+4°CPurity≥99%(HPLC)CASNumber883031-03-6PubChemID2742550InChIKeyNCZYSQOTAYFTNM-UHFFFAOYSA-NSmilesCC1=C(C(NC4=CC(C(F)(F)F)=CC=C4)=O)C=C(C3=CC=CC=C3)N1CCCN2CCOCC2Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO47.15100ethanol11.7925PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight471.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.12mL10.6mL21.21mL5mM0.42mL2.12mL4.24mL10mM0.21mL1.06mL2.12mL50mM0.04mL0.21mL0.42mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Everaertsetal(2010)InhibitionofthecationchannelTRPV4improvesbladderfunctioninmiceandratswithcyclophosphamide-inducedcystitis.Proc.Natl.Acad.Sci.10719084PMID:Keywords:HC067047,supplier,HC067047,trpv4,transient,receptor,potential,channels,potent,selective,antagonists,TRPV,TRPV,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
