Description:Potent,selectiveCB2agoNIST(inwater-solubleemulsion)ChemicalName:(6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyranBIOLOGicalActivityTechnicalDataDatasheetsReferencesBiologicalActivityPotentCB2selectiveagonist(Ki=3.4nM),inwater-solubleemulsion(fordetailsseeTocrisolveTM100Cat.No.1684).Approx.200-foldselectiveoverCB1receptors.Activeinvivo,reducingspasticityinamurinemodelofmultiplesclerosis.JWH133alsoavailableasasolid(Cat.No.1343).TechnicalDataM.Wt312.49FormulaC22H32OStorageStoreat+4°CCASNumber259869-55-1PubChemID6918505InChIKeyYSBFLLZNALVODA-RBUKOAKNSA-NSmiles[H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight312.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.2mL16mL32mL5mM0.64mL3.2mL6.4mL10mM0.32mL1.6mL3.2mL50mM0.06mL0.32mL0.64mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Bakeretal(2000)CannABInoidscontrolspasticityandtremorinamultiplesclerosismodel.Nature40484PMID:10716447Huffmanetal(1999)3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THCandrelatedcompounds:synthesisofselectiveligandsfortheCB2receptor.Bioorg.Med.Chem.72905PMID:10658595Pertwee(1999)Pharmacologyofcannabinoidreceptorligands.Curr.Med.Chem.6635PMID:10469884Keywords:JWH133(inTocrisolve100),supplier,Potent,selective,CB2,agonists,water-soluble,emulsion,cannabinoids,Receptors,JWH133,cb2r,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
