Description:CB2agoNISTChemicalName:N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityCB2receptoragonist.Displays4-foldhigheraffinityforthehumanCB2receptorthanthehumanCB1receptor(Kivaluesare43.3and162.4nMrespectively);shows70-foldaffinityfortheratCB2receptorovertheratCB1receptor(Kivaluesare16.3and1130nMrespectively).Attenuatestactileallodyniainaratmodel;doesnotaffectratlocomotoractivity.TechnicalDataM.Wt349.43FormulaC21H23N3O2StorageStoreat+4°CPurity≥99%(HPLC)CASNumber1048973-47-2PubChemID25034599InChIKeyZGQHMZCITJHYOW-QOCHGBHMSA-NSmilesO=C(C3=CC=CC=C3)NN=C(C1=CC=CC=C1N2CCCCCC)/C2=OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO17.4750ethanol17.4750PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight349.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.86mL14.31mL28.62mL5mM0.57mL2.86mL5.72mL10mM0.29mL1.43mL2.86mL50mM0.06mL0.29mL0.57mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Diazetal(2008)DesignandsynthesisofanovelseriesofN-alkylisatinacylhydrazonederivativesthatactasselectivecannABInoidreceptor2agonistsforthetreatmentofneuropathicpain.J.Med.Chem.514932PMID:18666769Xuetal(2010)Pharmacologicalcharacterizationofanovelcannabinoidligand,MDA19,fortreatmentofneuropathicpain.Anesth.Analg.11199PMID:20522703Keywords:MDA19,supplier,MDA19,cb2,cannabinoid,agonists,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
