Description:Inhibitssynaptosomaldopamineand5-HTuptakeChemicalName:(±)-2-Methylamino-1-(4-methylphenyl)propan-1-onehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityInhibitsstriataldopamineuptakeandhippocampal5-HTuptakeinsynaptosomes(IC50valuesare467and558nMrespectively).AdmiNISTrationcausesadecreaseindopamineand5-HTtransporterfunction.SyntheticCNSstimulant;brainpenetrant.TechnicalDataM.Wt213.7FormulaC11H15NO.HClStorageStoreatRTPurity≥99%(HPLC)CASNumber1189726-22-4PubChemID46782120InChIKeyDLQZFTUKJGRPLZ-UHFFFAOYSA-NSmilesCC1=CC=C(C(C(C)NC)=O)C=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO21.37100ethanol10.6950water21.37100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight213.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM4.68mL23.4mL46.79mL5mM0.94mL4.68mL9.36mL10mM0.47mL2.34mL4.68mL50mM0.09mL0.47mL0.94mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Hadlocketal(2011)4-methylmethcathinone(mephedrone):neuropharmacologicaleffectsofadesignerstimulantofabuse.J.Pharmacol.Exp.Ther.339530PMID:21810934Keywords:Mephedronehydrochloride,supplier,inhibitors,inhibits,dopamine,da,5-ht,SEROtonin,uptake,transporters,brain,penetrant,Dopamine,Transporters,5-HT,Transporters,Dopamine,Transporters,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
