Description:EndogenousCB1agoNIST.AlsovanilloidagonistandinhibitorofFAAHandAMTAlternativeNames:N-Arachidonyldopamine,AA-DAChemicalName:N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamideBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentendogenouscannABInoidandvanilloidreceptoragonist,withnoactionatdopaminereceptors.SelectiveforCB1overCB2receptors(Kivaluesare0.25and12μMrespectively),andpotentagonistatTRPV1(VR1)receptors(EC50~50nM).MetabolicallystableandcompetitivelyinhibitsFAAHandanandamidetransport.Hascannabinoidandvanilloidactionsinvivo.TechnicalDataM.Wt439.64FormulaC28H41NO3StorageDesiccateat-20°CCASNumber199875-69-9PubChemID5282105InChIKeyMVVPIAAVGAWJNQ-DOFZRALJSA-NSmilesO=C(NCCC1=CC=C(O)C(O)=C1)CCCC=C/CC=C/C/C=CC/C=CCCCCCThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolubilitySolubleinethanol(suppliedpre-dissolvedinanhydrousethanol,5mg/ml)PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight439.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.27mL11.37mL22.75mL5mM0.45mL2.27mL4.55mL10mM0.23mL1.14mL2.27mL50mM0.05mL0.23mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Bisognoetal(2000)N-acyl-dopamines:novelsyntheticCB1cannabinoid-receptorligandsandinhibitorsofanandamideinactivationwithcannabimimeticactivityinvitroandinvivo.Biochem.J.351817PMID:11042139DePetrocellisetal(2000)OverlapbetweentheligandrecognitionpropertiesoftheanandamidetransporterandtheVR1vanilloidreceptor:inhibitorsofanandamideuptakewithnegligIBLecapsaicin-likeactivity.FEBSLett.48352PMID:11033355Huangetal(2002)Anendogenouscapsaicin-likesubstancewithhighpotencyatrecombinantandnativevanilloidVR1receptors.Proc.Natl.Acad.Sci.U.S.A.998400PMID:12060783Keywords:NADA,supplier,Endogenous,CB1,agonists,vanilloid,inhibitors,inhibits,FAAH,AMT,TRPV1,cannabinoids,Receptors,Vanillioids,VR1,Channels,Transient,Receptor,Potential,cb1r,N-Arachidonyldopamine,AA-DA,CB1,Receptors,TRPV,CB1,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌,其产品也广为各大药厂、大学、研究机构,超过五万名科学研究者所采用。 目前,產品內容已超過一千六百種以上,並每年持續不斷的增加新的產品。目前,产品内容已超过一千六百种以上,并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔(Bristol)的高品质试剂提供商,共有2000多种产品,主要集中在神经科学和信号传导领域,产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等,主要产品包括GPCR ligands,神经传递素,离子通道调控剂,信号通路抑制剂等,这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者,其生产的影响神经系统的化学物质被多次引用,这些物质很多都来自Jeff Watkins(Tocris 的创立人)在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括:
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分:
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System