产品说明
Description:FullκagoNIST,partialμandδagonistandantagonizesagonist-inducedactivationofNOPAlternativeNames:NalBzOHChemicalName:[(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]benzoicacidhydrazidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityMixedopioidreceptoragonist/antagonist.Actsasapotentandfullagonistatκ,apartialagonistatμandδopioidreceptors(pEC50valuesare9.45,8.74and8.61inacAMPassay,9.70,8.59and8.49ina[35S]GTPγSbindingassayrespectively).FailstoexertagonisteffectsatNOPreceptorsandantagonizesagonist-inducedNOPactivation.Stimulatesκ-,μ-andδ-mediatedanalgesiaandblocksNOP-inducedsupraspinalnociception.TechnicalDataM.Wt445.52FormulaC26H27N3O4StorageDesiccateat+4°CPurity≥99%(HPLC)CASNumber119630-94-3PubChemID9601084InChIKeyAKXCFAYOTIEFOH-XTNAHFASSA-NSmilesO[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=CThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO22.2850PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight445.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.24mL11.22mL22.45mL5mM0.45mL2.24mL4.49mL10mM0.22mL1.12mL2.24mL50mM0.04mL0.22mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.ConnorandKitchen(2006)Hasthesunsetonκ3-opioidreceptors?Br.J.Pharmacol147349PMID:16402044Gistraketal(1989)Pharmacologicalactionsofanovelmixedopiateagonist/antagonist:naloxonebenzoylhydrazoneJ.Pharmacol.Exp.Ther.251469PMID:2553921Olianasetal(2006)Agonistactivityofnaloxonebenzoylhydrazoneatrecombinantandnativeopioidreceptors.Br.J.Pharmacol.147360PMID:16402046Keywords:Naloxonebenzoylhydrazone,supplier,κ-opioid,kappa-opioid,agonists,partial,μ-opioid,mu-opioid,δ-opioid,delta-opioid,antagonists,NOP,Opioids,Receptors,NalBzOH,Miscellaneous/Non-selective,Opioids,Miscellaneous/Non-selective,Opioids,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
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关于 Tocris | Tocris 生物科学,Tocris/SB 265610/2724/1/1 mg
