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Tocris/Noladin ether/1411/25/25 mg

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Description: Endogenous agonist for CB1 and GPR55 Alternative Names: HU 310, 2-Arachidonyl glycerol ether Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol Biological Activity Technical Data Solubility Calculators Datasheets References Biological Activity Endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55. Technical Data M. Wt 364.57 Formula C23H40O3 Storage Desiccate at -20°C CAS Number 222723-55-9 PubChem ID 6483057 InChI Key CUJUUWXZAQHCNC-DOFZRALJSA-N Smiles CCCCCC=C/CC=C/C/C=CC/C=CCCCCOC(CO)CO The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only. Solubility Data SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) Preparing Stock Solutions The following data is based on the product molecular weight 364.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg 1 mM 2.74 mL 13.71 mL 27.43 mL 5 mM 0.55 mL 2.74 mL 5.49 mL 10 mM 0.27 mL 1.37 mL 2.74 mL 50 mM 0.05 mL 0.27 mL 0.55 mL Molarity Calculator Molarity Calculator Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator Reconstitution Calculator Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Product Datasheets Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS References References are publications that support the products' biological activity. Duncan et al (2004) Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor. Br.J.Pharmacol. 142 509 PMID: 15148262 Hanus et al (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc.Natl.Acad.Sci.U.S.A. 98 3662 PMID: 11259648 Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302 Sugiura et al (1999) Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 274 2794 PMID: 9915812 Suhara et al (2000) Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Chem.Pharm.Bull. 48 903 PMID: 10923815 Keywords: Noladin ether, supplier, Endogenous, agonists, GPR55, CB1, Cannabinoids, Receptors, HU310, cb1r, HU, 310, 2-Arachidonyl, glycerol, ether, CB1, Receptors, GPR55, CB1, Receptors, Tocris Bioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins