Description:Potent,non-competitiveNMDAantagoNIST;antinociceptiveChemicalName:2-Amino-2-(2-chlorophenyl)cyclohexanonehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityMajormetaboliteofketaminethatisapotentnon-competitiveNMDAreceptorantagonist(Ki=3.6μMfordisplacementof[3H]-MK801inratbrain).Antinociceptiveandanestheticinvivo.R-enantiomerandS-enantiomeralsoavailable.LicensingInformationSoldforresearchpurposesunderagreementfromPfizerInc.TechnicalDataM.Wt260.16FormulaC12H14ClNO.HClStorageDesiccateatRTPurity≥99%(HPLC)CASNumber79499-59-5PubChemID25195026InChIKeyCLPOJGPBUGCUKT-UHFFFAOYSA-NSmilesCl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilitywater26.02100phosphatebufferedsaline26.02100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight260.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.84mL19.22mL38.44mL5mM0.77mL3.84mL7.69mL10mM0.38mL1.92mL3.84mL50mM0.08mL0.38mL0.77mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Leungetal(1986)Comparativepharmacologyintheratofketamineanditstwoprincipalmetabolites,norketamineand(Z)-6-hydroxynorketamine.J.Med.Chem.292396PMID:3783598Ebertetal(1997)Norketamine,themainmetaboliteofketamine,isanon-competitiveNMDAreceptorantagonistintheratcortexandspinalcord.Eur.J.Pharmacol.33399PMID:9311667Shimoyamaetal(1999)Oralketamineisantinociceptiveintheratformalintest:roleofthemetabolite,norketamine.Pain8185PMID:10353496Keywords:Norketaminehydrochloride,supplier,Potent,non-competitive,NMDA,antagonists,Glutamate,Receptors,N-Methyl-D-Aspartate,iGluR,Ionotropic,Pfizer,NMDA,Receptors,Ketamine,and,Metabolites,Ketamine,and,Metabolites,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
