Description:Anticonvulsant;selectivelybindstheα2δsubunitofvoltage-sensitivecalciumchannelsChemicalName:(S)-3-(Aminomethyl)-5-methylhexanoicacidBIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityAnticonvulsantandantiepileptic;alsousedtotreatneuropathicpain.Bindswithhighaffinityandselectivitytotheα2δsubunitofvoltage-sensitiveCa2+channelsandmodulatestheiractivity.Displaysanxiolytic-likeactivityinethologicalandconflictmodelsofanxiety.AnalogofGABA(Cat.No.0344).LicensingInformationSoldforresearchpurposesunderagreementfromPfizerInc.TechnicalDataM.Wt159.23FormulaC8H17NO2StorageStoreatRTCASNumber148553-50-8PubChemID5486971InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-NSmilesCC(C)C[C@H](CN)CC(O)=OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilitywater15.92100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight159.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM6.28mL31.4mL62.8mL5mM1.26mL6.28mL12.56mL10mM0.63mL3.14mL6.28mL50mM0.13mL0.63mL1.26mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Fieldetal(2001)Pregabalinmayrepresentanovelclassofanxiolyticagentswithabroadspectrumofactivity.Br.J.Pharmacol.1321PMID:11156553Kumaretal(2010)Evidencethatpregabalinreducesneuropathicpainbyinhibitingthespinalreleaseofglutamate.J.NeuRochem.113552PMID:20132471Arain(2009)Pregabalininthemanagementofpartialepilepsy.Neuropsych.Dis.Treat.5407PMID:Keywords:Pregabalin,supplier,anticonvulsants,neuropathic,pain,GABA,analgesics,anxiolytics,a2d,alpha2delta,α2δ,voltage-sensitive,calcium,channels,Ca2+,Voltage-gated,Calcium,Channels,Voltage-gated,Calcium,Channels,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
