Description:NegativeallostericmodulatoratPAR1receptorChemicalName:1-[(4-Chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazolehydrochloridePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPAR1negativeallostericmodulator(IC50=916nM);inhibitsPAR1-Gαqinteraction.SelectiveforPAR1overPAR2.Blocksthrombin-inducedintracellularcalciummobilization(IC50=10.3nM),CCL2expression,ERK1/2andMLCphosphorylation,andIP3productionincells.TechnicalDataM.Wt369.29FormulaC21H17ClN2.HClStorageStoreat+4°CPurity≥99%(HPLC)CASNumber1052076-77-3PubChemID16258217InChIKeyWXIWQTVPWYFEHP-UHFFFAOYSA-NSmilesClC(C=C4)=CC=C4CN2C1=CC=CC=C1N=C2CC3=CC=CC=C3.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO18.4650ethanol18.4650PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight369.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.71mL13.54mL27.08mL5mM0.54mL2.71mL5.42mL10mM0.27mL1.35mL2.71mL50mM0.05mL0.27mL0.54mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Dengetal(2008)ThrombininducesfibroblastCCL2/JEproductionandreleaseviacouplingofPAR1toGαqandcooperationbetweenERK1/2andRhokinasesignalingpathways.Mol.Biol.Cell192520PMID:18353977Asteritietal(2012)ModulationofPAR1signallingbybenzimidazolecompounds.Br.J.Pharmacol.16780PMID:22519452Scottonetal(2009)IncreasedlocalexpressionofcoagulationfactorXcontributestothefibroticresponseinhumanandmurinelunginjury.J.Clin.Invest.1192550PMID:19652365Keywords:Q94hydrochloride,supplier,PAR1,protease,activated,receptors,negative,allosteric,modulators,selective,blocks,thrombin,induced,calcium,mobilization,Protease-Activated,Receptors,Protease-Activated,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
