Description:Potent,selectiveCB2agoNISTAlternativeNames:COR167ChemicalName:N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectiveCB2receptoragonist(Kivaluesare6.3nMand1.2μMforCB2andCB1receptorsrespectively).Displaysanalgesicactivityintheformalintestinmice.TechnicalDataM.Wt434.61FormulaC28H38N2O2StorageStoreatRTPurity≥99%(HPLC)CASNumber1048038-90-9PubChemID25034551InChIKeyKUMKLUDNETVLDS-UHFFFAOYSA-NSmilesO=C(C4=CN(CCCCC)C5=C(C=C(C(C)C)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO10.8725ethanol21.7350PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight434.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.3mL11.5mL23.01mL5mM0.46mL2.3mL4.6mL10mM0.23mL1.15mL2.3mL50mM0.05mL0.23mL0.46mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Pasquinietal(2008)Investigationsonthe4-quinolone-3-carboxylicacidmotif.2.Synthesisandstructure-activityrelationshipofpotentandselectivecannABInoid-2receptoragonistsendowedwithanalgesicactivityinvivo.J.Med.Chem.515075PMID:18680276Contartese(2012)AnovelCB2agonist,COR167,potentlyprotectsratbraincorticalslicesagainstOGDandreperfusioninjury.Pharmacol.Res.66555PMID:23036353Keywords:SER601,supplier,Potent,selective,CB2,receptors,agonists,analgesic,cannabinoids,SER601,cb2r,COR,167,COR167,COR,167,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
